| 세션명 | 콜로이드 및 분자조립 부문위원회 (I) |
|---|---|
| 발표장 | 제3회장 |
| 논문코드 | 1L3-2 |
| 발표일 | 2021-10-21 |
| 발표시간 | 14:25-14:50 |
| 논문제목 | Intracellular polymerization and self-assembly for supramolecular approach to control cellular fate |
| 발표자 | 유자형 |
| 발표자 소속 | 울산과학기술원 |
| 저자 | 유자형† |
| 소속 | 울산과학기술원 |
| 논문초록 | The polymerization-induced artificial assembly of synthetic building units inside a living cell and the interaction of these assembly with the cellular components have rarely been studied, but are emerging as an intriguing strategy to control cellular fate. We developed intra-mitochondrial polymerization induced self-assembly (Mito-PISA) strategy for constructing polymeric structures by ROS-dissipative system. We report that the in situ disulfide polymerization inside mitochondria is based on both large accumulation of monomers (increased local concentration for polymerization) and high ROS environment (chemical fuel for disulfide reaction). During the polymerization in a mitochondrial reducing environment, the autocatalytic process enables the continuous generation of ROS and the construction of bulky structures for mitochondrial dysfunction, showing great potential for anticancer treatment. |
THE POLYMER SOCIETY OF KOREA